Serie A
4th tour
Lazio
21 September
06:30
(EDT)
AS Roma

Lazio vs AS Roma: prediction & betting odds September 21, 2025

The Matchday 4 clash in Serie A between Lazio and Roma will take place on September 21 at the Stadio Olimpico in Rome. Lazio vs. Roma: prediction and betting odds, statistics.

Lazio

Maurizio Sarri's side suffered a setback in their last away match against Sassuolo (0-1). As a result, Lazio recorded their second defeat in this championship, failing to score in both instances. Additionally, the club has failed to keep a clean sheet in five of their last six Serie A matches. In the standings, Lazio has three points and is currently in 12th place.


  • The team has not won in 5 of their last 6 Serie A matches (2 draws, 3 losses).
  • No more than 2 goals have been scored in 9 of the club's last 12 league fixtures.
  • At least one of the opponents failed to score in 5 of Lazio's last 7 Serie A matches.

Predicted lineup for Lazio (4-3-3)*

Ivan Provedel – Adam Marusic, Mario Gila, Alessio Romagnoli, Nuno Tavares – Matteo Guendouzi, Nicolo Rovella, Fisayo Dele-Bashiru – Matteo Cancellieri, Valentin Castellanos, Mattia Zaccagni.


Midfielder Manuel Lazzari will miss the match due to injury. Midfielder Nicolo Rovella's participation is also in doubt due to injuries.

Roma

In the previous round, Gian Piero Gasperini's side unexpectedly lost at home to Torino (0-1). As a result, Roma's four-match winning streak in the championship came to an end, and they conceded their first goal in this Serie A season. With six points, the team has dropped to sixth place in the standings. Notably, Roma has conceded only one goal this Serie A season and, along with Napoli, ranks among the top two clubs in this regard.


  • The team has not lost in 23 of their last 25 league matches (18 wins, 5 draws).
  • The club's players have not scored more than once in 12 of their previous 14 Serie A matches.
  • At least one of the opponents failed to score in 7 of Roma's last 9 league matches.

Predicted lineup for Roma (3-4-3)*

Mile Svilar – Evan Ndicka, Gianluca Mancini, Mario Hermoso – Wesley Fofana, Kouadio Kone, Bryan Cristante, Angelino – Neil El Aynaoui, Paulo Dybala, Matias Soule.


Defender Mario Hermoso, midfielder Leon Bailey, and forward Paulo Dybala will miss the match due to injuries. Defender Wesley Fofana's participation is also in doubt due to illness.

Referee

Simone Sozza (Italy)


Matches – 18 (Serie A, 2024/25–2025/26);

Yellow cards shown (including second yellows) – 65;

Average yellow cards per match – 3.6;

Red cards shown – 1;

Average fouls per match – 24;

Penalties – 44%.

Lazio vs. Roma: Match Prediction

Maurizio Sarri's side has been inconsistent in the early rounds of the current championship, with attacking issues being particularly noticeable. In this Serie A season, Lazio failed to score against Como and Sassuolo and has generally struggled in attack in recent matches. In their last 14 league games, the team has only managed to score more than once on four occasions and has failed to score in four matches during this period.


Roma is also not particularly prolific and rarely delights their fans with attacking prowess: in 12 of their last 14 Serie A encounters, the team has not breached the opponent's defense more than once. However, defensively, the club is solid and effectively neutralizes threats from opponents: in their last 21 league matches, Roma has only conceded more than one goal once and has kept a clean sheet in 12 games during this period.


I don't expect many goals in this match, so my prediction: Total under 2.5 goals


* The starting lineup for each team in their last match in this tournament is indicated.

Lazio vs AS Roma Odds

1X2
DOUBLE CHANCE
OVER/UNDER
BTTS
TOTAL HOME GOALS
TOTAL AWAY GOALS

Current season

Logo Lazio Logo Roma
1 Wins 2
2 Lost 1
1.33 GF per game 0.67
1 GA per game 0.33
5 Corners per game 5.33
2 Yellow cards per game 1.33

Serie A: previous matches of the tournament

Lazio
09/14/25
Sassuolo
Lazio
L
08/31/25
Lazio
Hellas Verona
W
08/24/25
Como
Lazio
L
More games
AS Roma
09/14/25
AS Roma
Torino
L
08/30/25
Pisa
AS Roma
W
08/23/25
AS Roma
Bologna
W
More games

Head-to-Head: Lazio — AS Roma

Serie A 2024-2025
04/13/25
Lazio
AS Roma
01/05/25
AS Roma
Lazio
Serie A 2023-2024
04/06/24
AS Roma
Lazio
Coppa Italia 2023-2024
01/10/24
Lazio
AS Roma
Serie A 2023-2024
11/12/23
Lazio
AS Roma
Serie A 2022-2023
03/19/23
Lazio
AS Roma
11/06/22
AS Roma
Lazio
Serie A 2021-2022
03/20/22
AS Roma
Lazio
09/26/21
Lazio
AS Roma
Serie A 2020-2021
05/15/21
AS Roma
Lazio
01/15/21
Lazio
AS Roma
Serie A 2019-2020
01/26/20
AS Roma
Lazio
09/01/19
Lazio
AS Roma
Serie A 2018-2019
03/02/19
Lazio
AS Roma
09/29/18
AS Roma
Lazio
Serie A 2017-2018
04/15/18
Lazio
AS Roma
11/18/17
AS Roma
Lazio
Serie A 2016-2017
04/30/17
AS Roma
Lazio
12/04/16
Lazio
AS Roma
Serie A 2015-2016
04/03/16
Lazio
AS Roma
11/08/15
AS Roma
Lazio
Serie A 2014-2015
05/25/15
Lazio
AS Roma
01/11/15
AS Roma
Lazio
Serie A 2013-2014
02/08/14
Lazio
AS Roma
0
:
0
09/21/13
AS Roma
Lazio
2
:
0
Serie A 2012-2013
04/07/13
AS Roma
Lazio
1
:
1
11/10/12
Lazio
AS Roma
3
:
2
Serie A 2011-2012
03/03/12
AS Roma
Lazio
1
:
2
10/15/11
Lazio
AS Roma
2
:
1
Serie A 2010-2011
03/12/11
AS Roma
Lazio
2
:
0
11/06/10
Lazio
AS Roma
0
:
2
Serie A 2009-2010
04/17/10
Lazio
AS Roma
1
:
2
12/05/09
AS Roma
Lazio
1
:
0
Serie A 2008-2009
04/10/09
Lazio
AS Roma
4
:
2
11/15/08
AS Roma
Lazio
1
:
0
Serie A 2007-2008
03/18/08
Lazio
AS Roma
3
:
2
10/30/07
AS Roma
Lazio
3
:
2
Serie A 2006-2007
04/28/07
AS Roma
Lazio
0
:
0
12/09/06
Lazio
AS Roma
3
:
0
Serie A 2005-2006
02/25/06
Lazio
AS Roma
0
:
2
10/22/05
AS Roma
Lazio
1
:
1
Serie A 2004-2005
05/14/05
AS Roma
Lazio
0
:
0
01/05/05
Lazio
AS Roma
3
:
1
More games

Standings

Team Games W T L Goals Points Form
1
Juventus
4 3 1 0 8:4 10
2
Napoli
3 3 0 0 6:1 9
3
AC Milan
4 3 0 1 7:2 9
4
Cremonese
3 2 1 0 5:3 7
5
Cagliari
4 2 1 1 5:3 7
6
Udinese
4 2 1 1 4:5 7
7
AS Roma
3 2 0 1 2:1 6
8
Bologna
4 2 0 2 3:3 6
9
Atalanta
3 1 2 0 6:3 5
10
Como
3 1 1 1 3:2 4
11
Torino
3 1 1 1 1:5 4
12
Inter Milan
3 1 0 2 9:6 3
13
Lazio
3 1 0 2 4:3 3
14
Sassuolo
3 1 0 2 3:5 3
15
Hellas Verona
4 0 3 1 2:6 3
16
Fiorentina
3 0 2 1 2:4 2
17
Genoa
4 0 2 2 2:4 2
18
Pisa
3 0 1 2 1:3 1
19
Parma
3 0 1 2 1:5 1
20
Lecce
4 0 1 3 2:8 1
Team Games W T L Goals Points Form
1
Juventus
2 2 0 0 6:3 6
2
Bologna
2 2 0 0 3:1 6
3
Cagliari
2 1 1 0 3:1 4
4
Atalanta
2 1 1 0 5:2 4
5
Como
2 1 1 0 3:1 4
6
Napoli
1 1 0 0 1:0 3
7
AC Milan
2 1 0 1 2:2 3
8
Cremonese
1 1 0 0 3:2 3
9
AS Roma
2 1 0 1 1:1 3
10
Inter Milan
2 1 0 1 6:2 3
11
Lazio
1 1 0 0 4:0 3
12
Sassuolo
2 1 0 1 1:2 3
13
Hellas Verona
2 0 2 0 1:1 2
14
Udinese
2 0 1 1 1:4 1
15
Torino
1 0 1 0 0:0 1
16
Genoa
2 0 1 1 0:1 1
17
Parma
1 0 1 0 1:1 1
18
Fiorentina
1 0 0 1 1:3 0
19
Pisa
2 0 0 2 0:2 0
20
Lecce
2 0 0 2 1:4 0
Team Games W T L Goals Points Form
1
Napoli
2 2 0 0 5:1 6
2
AC Milan
2 2 0 0 5:0 6
3
Udinese
2 2 0 0 3:1 6
4
Juventus
2 1 1 0 2:1 4
5
Cremonese
2 1 1 0 2:1 4
6
Cagliari
2 1 0 1 2:2 3
7
AS Roma
1 1 0 0 1:0 3
8
Torino
2 1 0 1 1:5 3
9
Fiorentina
2 0 2 0 1:1 2
10
Atalanta
1 0 1 0 1:1 1
11
Hellas Verona
2 0 1 1 1:5 1
12
Genoa
2 0 1 1 2:3 1
13
Pisa
1 0 1 0 1:1 1
14
Lecce
2 0 1 1 1:4 1
15
Bologna
2 0 0 2 0:2 0
16
Como
1 0 0 1 0:1 0
17
Inter Milan
1 0 0 1 3:4 0
18
Lazio
2 0 0 2 0:3 0
19
Sassuolo
1 0 0 1 2:3 0
20
Parma
2 0 0 2 0:4 0

Team Rosters

The line-ups will be known a few hours before kick-off
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