Serie A
4th tour
Napoli
22 September
14:45
(EDT)
Pisa

Napoli vs Pisa: prediction & betting odds September 22, 2025

The Matchday 4 clash in Serie A between Napoli and Pisa will take place on September 22 at the Diego Armando Maradona Stadium. Napoli vs. Pisa: prediction and betting odds, statistics.

Napoli

In the previous round, Antonio Conte's side secured a 3-1 away victory against Fiorentina. As a result, Napoli extended their winning streak in the league to four matches, although they conceded for the first time in five previous Serie A encounters. At the same time, the team managed to score more than two goals for the first time in their last nine league games. With nine points, Napoli leads the standings, ahead of Juventus in second place on goal difference.


  • The club has won 6 of their last 7 home matches in Serie A.
  • The team scored exactly 1 or 2 goals in 11 of their last 12 home league games.
  • No more than two goals have been scored in 7 of Napoli's last 9 Serie A matches.

Projected lineup for Napoli (4-5-1)

Vanja Milinković-Savić – Giovanni Di Lorenzo, Sam Beukema, Alessandro Buongiorno, Leonardo Spinazzola – Matteo Politano, Kevin De Bruyne, Stanislav Lobotka, André-Frank Zambo Anguissa, Scott McTominay – Rasmus Højlund.


Defender Amir Rrahmani and forward Romelu Lukaku will miss the game due to injuries.

Pisa

Alberto Gilardino's side suffered a 0-1 home defeat to Udinese in the last round. This marks Pisa's second consecutive loss in the current league campaign, with the team failing to score in both matches. Notably, Pisa has conceded exactly one goal in each of their three Serie A matches this season. In the standings, Pisa has one point and sits in 18th place.


  • The team has not lost in 8 of their last 11 away matches in Serie A and Serie B (5 wins, 3 draws).
  • The club has not conceded more than one goal in 11 of their last 12 away league games.
  • A maximum of two goals have been scored in 5 of Pisa's last 7 matches in Serie A and Serie B.

Projected lineup for Pisa (3-5-2)

Adrian Šemper – Simone Canestrelli, Antonio Caracciolo, Mateus Luzardi – Idrissa Touré, Michel Aebischer, Ebenezer Akinsanmiro, Stefano Moreo, Samuele Angori – Matteo Tramoni, Henrik Meister.


Midfielder Juan Cuadrado will miss the match due to injury.

Referee

Valerio Crezzini (Italy)


Matches – 16 (Serie A and Serie B, 2024/25–2025/26);

Yellow cards shown (including second yellows) – 58;

Average yellow cards per match – 3.6;

Red cards shown – 0;

Average fouls per match – 30;

Penalties – 19%.

Napoli vs. Pisa: Match Prediction

Antonio Conte's side performs confidently at home, but they can't boast of very high scoring. Even when winning, the team often limits itself to a small number of goals: in their last 16 home Serie A matches, Napoli has only scored more than two goals once. In eight matches during this period, the club's players have scored a maximum of one goal.


Pisa prefers to play on the counter and focuses primarily on solid defense. Even away from home, the team concedes few goals: in 10 of their last 11 away matches in Serie A and Serie B, the club has not allowed their opponents to score more than one goal. Additionally, Pisa managed to keep a clean sheet in four encounters during this period.


Considering that Napoli also faced additional workload in the Champions League ahead of this round, I do not expect a high number of goals from the hosts. My prediction: Napoli individual total under 2.5


* Each team's starting lineup is based on their last match in this tournament.

Napoli vs Pisa Odds

1X2
DOUBLE CHANCE
OVER/UNDER
BTTS
TOTAL HOME GOALS
TOTAL AWAY GOALS

Current season

Logo Napoli Logo Pisa
3 Wins 0
0 Lost 2
0 Draws 1
2 GF per game 0.33
0.33 GA per game 1
6.67 Corners per game 4.33
1 Yellow cards per game 1

Serie A: previous matches of the tournament

Napoli
09/13/25
Fiorentina
Napoli
W
08/30/25
Napoli
Cagliari
W
08/23/25
Sassuolo
Napoli
W
More games
Pisa
09/14/25
Pisa
Udinese
L
08/30/25
Pisa
AS Roma
L
08/24/25
Atalanta
Pisa
T
More games

Standings

Team Games W T L Goals Points Form
1
Juventus
4 3 1 0 8:4 10
2
Napoli
3 3 0 0 6:1 9
3
AC Milan
4 3 0 1 7:2 9
4
AS Roma
4 3 0 1 3:1 9
5
Atalanta
4 2 2 0 9:3 8
6
Cremonese
4 2 2 0 5:3 8
7
Cagliari
4 2 1 1 5:3 7
8
Como
4 2 1 1 5:3 7
9
Udinese
4 2 1 1 4:5 7
10
Bologna
4 2 0 2 3:3 6
11
Torino
4 1 1 2 1:8 4
12
Inter Milan
3 1 0 2 9:6 3
13
Sassuolo
3 1 0 2 3:5 3
14
Lazio
4 1 0 3 4:4 3
15
Hellas Verona
4 0 3 1 2:6 3
16
Genoa
4 0 2 2 2:4 2
17
Fiorentina
4 0 2 2 3:6 2
18
Parma
4 0 2 2 1:5 2
19
Pisa
3 0 1 2 1:3 1
20
Lecce
4 0 1 3 2:8 1
Team Games W T L Goals Points Form
1
Juventus
2 2 0 0 6:3 6
2
Bologna
2 2 0 0 3:1 6
3
Atalanta
2 1 1 0 5:2 4
4
Cremonese
2 1 1 0 3:2 4
5
Cagliari
2 1 1 0 3:1 4
6
Como
2 1 1 0 3:1 4
7
Napoli
1 1 0 0 1:0 3
8
AC Milan
2 1 0 1 2:2 3
9
AS Roma
2 1 0 1 1:1 3
10
Inter Milan
2 1 0 1 6:2 3
11
Sassuolo
2 1 0 1 1:2 3
12
Lazio
2 1 0 1 4:1 3
13
Hellas Verona
2 0 2 0 1:1 2
14
Udinese
2 0 1 1 1:4 1
15
Torino
2 0 1 1 0:3 1
16
Genoa
2 0 1 1 0:1 1
17
Parma
1 0 1 0 1:1 1
18
Fiorentina
2 0 0 2 2:5 0
19
Pisa
2 0 0 2 0:2 0
20
Lecce
2 0 0 2 1:4 0
Team Games W T L Goals Points Form
1
Napoli
2 2 0 0 5:1 6
2
AC Milan
2 2 0 0 5:0 6
3
AS Roma
2 2 0 0 2:0 6
4
Udinese
2 2 0 0 3:1 6
5
Juventus
2 1 1 0 2:1 4
6
Atalanta
2 1 1 0 4:1 4
7
Cremonese
2 1 1 0 2:1 4
8
Cagliari
2 1 0 1 2:2 3
9
Como
2 1 0 1 2:2 3
10
Torino
2 1 0 1 1:5 3
11
Fiorentina
2 0 2 0 1:1 2
12
Hellas Verona
2 0 1 1 1:5 1
13
Genoa
2 0 1 1 2:3 1
14
Parma
3 0 1 2 0:4 1
15
Pisa
1 0 1 0 1:1 1
16
Lecce
2 0 1 1 1:4 1
17
Bologna
2 0 0 2 0:2 0
18
Inter Milan
1 0 0 1 3:4 0
19
Sassuolo
1 0 0 1 2:3 0
20
Lazio
2 0 0 2 0:3 0

Team Rosters

The line-ups will be known a few hours before kick-off
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